Eze Ejike Daniel, Aliyu Mohammed, Yusuf Tanko and Abubakar Ahmed receive Archimedes Research Award-2015 in Diabetology
23 March, 2015, Nigeria, USA NEWS CORP
Eze Ejike Daniel, Aliyu Mohammed, Yusuf Tanko and Abubakar Ahmed from Nigeria made a historical victory over the international competition and won Archimedes Research Award-2015 in Diabetology. Their research was highlighted in international media and gathered a large worldwide attention in scientific circles while it appeared in world's most read journal ' The Journal for Endocrinology and Metabolism'. In their report on Lycopene Ameliorates Atherogenic Cardiovascular Risk in Streptozotocin-Induced Diabetic Hyperlipidaemia in Wistar Rats they mention that Diabetes mellitus is a chronic metabolic disorder of the endocrine system and a risk factor for many cardiovascular diseases. Several studies have reported the beneficial roles of lycopene in the treatment of various ailments, but they were mainly epidemiological. This study was investigated the ameliorative effects of lycopene in atherogenecity of streptozotocin-induced diabetic hyperlipidaemia in Wistar rats. Diabetic rats were randomly divided into following groups: Group I: Normal control + OL (0.5 ml/kg b w), Groups II: Diabetic control + OL (0.5 ml/kg b w) respectively. Diabetic Groups III-V received 10 mg/kg b w, 20 mg/kg b w, 40 mg/kg b w of lycopene while Diabetic Groups VI + glibenclamide 2 mg/kg b w. There was a significant (p<0.05) reduction in blood glucose level. The results showed a significantly (p<0.05) decreased serum, TC, triglyceride and LDL levels with a corresponding elevated serum HDL level in diabetic-lycopene treated animals. Serum atherogenic risk predictor indices and cardiac risk ratio were significantly deceased (p<0.05) while HDL-cholesterol/TC was increased significantly (p<0.05) when compared with diabetic control group. It can be concluded that lycopene ameliorated atherogenic diabetic-induced dyslipidaemia, hence may have cardio-protective effects. Lycopene significantly (p<0.05) and dose dependently reduced blood glucose level in diabetic Wistar rats. The drug also significantly (p<0.05) decreased serum levels of total cholesterol, triglyceride and low-density lipoprotein with a corresponding elevated serum high-density lipoprotein level in diabetic-lycopene treated animals in comparison with the diabetic control group.. Under their leadership the research area is surely likely to expand beyond the horizons. It will be worthy to explore the further potential under their legacy. Eze Ejike Daniel, Aliyu Mohammed, Yusuf Tanko and Abubakar Ahmed as valuable intellectuals for the Nigeria offer exclusive opportunities for scholars around the world. One of the most attractive weightage for Nigeria is to have the awardees for promotion of the concerned scientific discipline for the benefit of its civilians. Thus Nigeria which has excellent track record to produce brain storming intellectuals, has offered a new extension in terms of Eze Ejike Daniel, Aliyu Mohammed, Yusuf Tanko and Abubakar Ahmed to world. International Agency for Standards and Ratings recognizes him among World's 500 Most Influential Diabetologist for the year 2015 on earth. Eze Ejike Daniel is Assistant Lecturer (Ph.D Student) at Department of Physiology, Faculty of Basic Medical Sciences, Bingham University, Karu, Nasarawa State, Nigeria. Aliyu Mohammed is Associate Professor at Department of Human Physiology, Ahmadu Bello University Zaria, Nigeria. Yusuf Tanko is Lecturer I at Department of Human Physiology, Ahmadu Bello University Zaria, Nigeria. Abubakar Ahmed is Senior Lecturer at Department of Pharmacognosy and Drug Development Ahmadu Bello University Zaria, Nigeria. This study suggests that lycopene could be a potential therapeutic agent for diabetic cardiovascular complications. This study was not able to elucidate the actual mechanism of lycopene action on the reported properties. Hence they recommend that: Further investigation on the effects of lycopene should be done on inflammatory markers of diabetic animals such as TNF-α, interleukin-1 (IL-1), interleukin-6 (IL-6), as elevations in inflammation maker activity has been reported to plays a critical role in several stages of microvascular and cardiovascular diseases that occurs in diabetes. Further studies should be carried out investigate the precise mechanism(s) involved in the protective effect of lycopene against atherogenic heart disease associated with diabetes mellitus. Diabetes mellitus is a chronic metabolic disorder affecting both developing and developed countries. There is need for government and private sectors to provide fund for research in order to develop more effective treatment that can be available for all. In conclusion, the results from the present study indicate that lycopene at various doses exert an ameliorative effect on hyperglycaemia, hyperlipidemia, as well as biomarkers of cardiovascular risk such as atherogenic index (AI) and cardiac risk ratio (CRR). This is evidenced by decreased elevated serum lipids TC, TRIG, LDL-C and increased the serum HDL-C levels in STZ-induced diabetic animals. Lycopene significantly (p<0.05) deceased serum atherogenic risk predictor indices (LDL-cholesterol/HDL-cholesterol, log (TRIG/HDL-cholesterol) and cardiac risk ratio while HDL-cholesterol/TC was increased significantly (p<0.05) when compared with diabetic control group. Lycopene significantly (p<0.05) deceased serum atherogenic risk predictor indices (LDL-cholesterol/HDL-cholesterol, log (TRIG/HDL-cholesterol) and cardiac risk ratio were significantly (p<0.05) while HDL-cholesterol/TC was increased significantly (p<0.05) when compared with diabetic control group. The authors of this work kindly wish to acknowledge the technical assistance of Laboratory staff, Department of Human Physiology Ahmadu Bello University, Zaria, Nigeria towards successful completion of this research work. You can share this News URL on Facebook or your Social Media Site/ blog. USA NEW SCORP If you have a news you can Submit your News in Comment box> Join us as Journalist > News Content purchase > Corrections > Copyright > Place a Classified Ad > Sell Your Home > Sell Your Business > Commercial Real Estate Ads > Advertise with us > Recruitment & Career Ads > Franchising > Advertise Locally > Contact us > firstname.lastname@example.org
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